Starvation And Associated Neuropathies In The Hippocampal Formation Of Adult Wistar Rats Rattus NorvegicusJournal: International Journal of Scientific & Technology Research (Vol.2, No. 1)
Publication Date: 2013-01-25
Authors : Fakunle P. B; Ajibade A. J;
Page : 34-39
Keywords : KEYWORDS- Hippocampus; Starvation; Rats; Pyramidal Neurons; Memory;
ABSTRACT- Neurohistological integrity of hippocampus when exposed to starvation was investigated in thirty adult wistar rats of average weight 200g . They were acclimatized for 2weeks on standard laboratory mouse chow and provided water ad libitum. They were subsequently randomly distributed into 3 groups n10 of Control C Treatment T1 and Treatment T2. Treatments T1 and T2 animals were exposed to starvation periods of 3 and 14days respectively and sacrificed by whole-body intracardiac perfusion fixation under gravity for routine histological techniques. Statistical analysis showed significant body weight loss P0.05 in T1Meansem 194.86.1g compared to the control section with Meansem225.06.21g.Histoarchitecture of treatment group T2 revealed distinct hippocampal subfields of CA1CA2CA3 and the DG Dentate Gyrus with pyknotic pyramidal cells and scantily distributed glial cells compared to the control these findings were less marked in the T1 cells while the control group cells appeared normal. Also significantlyP0.05 reduced neuronal population of 11 8 and 14 in CA1 CA2 and CA3 subfields respectively for Treatment group T1 compared to the control group.The neuronal transverse diameter for the pyramidal cells revealed statistically significantP0.05 values MeanSEM 1.200.01m was obtained in treatment group T1 compared to the control group.Long term starvation has severe and deleterious effects on the cellular integrity of hippocampus it may thus underline problems associated with memory and learning.
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