STUDIES OF EFFICIENCY OF THE COMPOSITE SYSTEM "LYMPHOSILICA" IN MODELING EXPERIMENTAL OBESITY IN RATS

The features of the influence of the nanocomposite system (Lymphosilica supplement), which was created on the basis of hydroconsolidated finely divided silica and plant materials with a high content of polyphenols, flavonoids, terpenes, polysaccharides on liver cytophysiological characteristics under the conditions of the development of metabolic syndrome and hepatotoxicity under simulated alimentary, were studied. Biochemical studies of blood serum and histological analysis of liver tissue were performed. It was shown that a high-calorie diet of rats over 100 days leads to the development of individual manifestations of obesity and metabolic syndrome, which are expressed in an increase in body weight and visceral fat, the development of the initial and middle stages of parenchymal fatty liver dystrophy with a decrease in morphological manifestations of the synthetic activity of the nucleus, with slight deviations at the biochemical level. The introduction of a phytocomposite does not lead to pathological changes in the organism of rats, but in some cases leads to manifestations of “adaptive stress” of liver hepatocytes, both with a standard diet and with a high-calorie diet. The positive effect of the composite system on reducing the proportion of visceral fat (by 38%) in rats with a standard diet was shown, and against the background of simulated alimentary obesity, normalization of the level of bilirubin (25 % decrease compared with alimentary obesity) and its fractions, lower levels cholesterol and alkaline phosphatase (in both cases by 19% compared with initial obesity), increased globulin fractions of blood serum, protective effect against dystrophic changes in liver tissue.