Evaluation of Apolipoprotein Profile and Cd4+ T Cell Count in Adult HIV Seropositives in Nauth Nnewi, South Eastern, Nigeria

Aim: To determine the Apolipoprotein profile and CD4+ T cell count in adult HIV seropositive participants in Nnamdi Azikiwe University Teaching Hospital Nnewi, South Eastern Nigeria. Methods: Blood samples collected from the 300 randomly recruited participants were used for HIV screening, CD4+ T cell count, Apolipoprotein A-1, A-11, B, C-11, C-111 and Apo E. Standard Laboratory methods were used for the analysis. Results: The results showed that the mean serum Apo A-11, Apo B, Apo C-11 and Apo E levels were significantly higher in symptomatic HIV participants not on antiretroviral therapy (ART) compared with asymptomatic HIV participants at P< 0.05, in each case. But the mean serum Apo A-1, Apo C-111 and CD4+ T cell levels were significantly lower in symptomatic HIV participants not on ART compared with asymptomatic HIV participants at P< 0.05, in each case. Also, the mean serum Apo A-11, Apo B and Apo E levels were significantly higher in symptomatic HIV participants not on ART compared with HIV seronegative control subjects at P<0.05 respectively. However, the mean serum Apo A-1, Apo C-111 and CD4+ T cell levels were significantly lower in symptomatic HIV participants not on ART compared with asymptomatic HIV participants at P<0.05 in each case. Again, the mean serum Apo A-11, Apo B, Apo E were significantly higher in asymptomatic HIV participants compared with HIV seronegative control subjects at P<0.05 in each case. But the mean serum Apo A-1, Apo C-11 and CD4+ T cell levels were significantly lower in asymptomatic HIV participants compared with HIV seronegative control subjects at P<0.05 in each case.