Synthesis and Antifungal Study of Some Acetophenone Oximes and Their Terphthaloyl Oxime Esters

Acetophenone oximes 1 – 5 along with their terphthaloyl oxime esters 6 – 10 have been synthesized in moderate to good yields. Only one oxime was formed in as E/Z two isomers in a ratio of (8:1). These resulting oxime derivatives were involved in an antifungal screening against the Aspergillus niger at concentration of 30 ppm. Two commercially available antifungal agents, clorotimazole and daktarin, were employed as references at the same concentration, 30 ppm. The antifungal results for the oxime derivatives 1 – 10 showed inhibitory levels ranging from 38% to 100%, whereas the antifungal potentials for the two references were found to be ~ 63% and 68% for clorotimazole and daktarin respectively.