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Journal: Indo American Journal of Pharmaceutical Sciences (IAJPS) (Vol.1, No. 4)

Publication Date:

Authors : ; ; ; ;

Page : 196-208

Keywords : Pioglitazone;

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Pioglitazone Controlled release tablets were prepared by using polymers like Hydroxy propyl methyl cellulose, Psyllium, Guar-gum, Xanthum gum and Carbopol. From this study it can be concluded that Pioglitazone C.R tablets prepared by Hydroxy propyl methyl cellulose K15M ( i.e. H3) showed good release rate than the tablets prepared by using other polymers. Pre compression and Carr’s index of the pure drug indicated that the drug had good flow property, even the formulations were found to be within the range. Post compression studies, for tablets like thickness, diameter, hardness, friability, drug content uniformity was done. The dissolution studies were carried out for 24 hours. As per the result of dissolution study of formulation H3, P3, G3 and X3 showed reasonable release 99.87%, 97.85%, 92.48% and 93.51% respectively at the end of 24hrs. Formula H3 showed good drug release profile 99.87% at the 24 hrs, showed excellent matrix integrity during the period of study, when compare to other formulations. The formulation H3 was considered optimum because it showed negligible drug release in acidic medium and drug release in the phosphate buffer (pH 7.4) was found to be almost complete. The stability studies of the selected formulation showed that the product was stable through-out the study period .

Last modified: 2014-10-15 17:57:06