Spectrophotometric Determination of Almotriptan Malate in Tablets Using Ammonium Molybdate and Phosphomolybdic Acid as Reagents

Two simple, sensitive visible spectrophotometric methods have been developed for the estimation of almotriptan malate either in pure or tablet dosage forms. These methods are based on the precipitate /color formation by the reaction of drug with either reagents PMA-Co(II)-EDTA at 840nm (Method A) or ammonium molybdate-potassium thiocyanate in acid medium at 465nm (Method B). Beer's law obeyed in the concentration range of 16-48 µg/ml and 4-20 µg/ml for method A and method B respectively. No interference was observed from the usually existing additives in pharmaceutical formulations and the applicability of the method was examined by analyzing AXERT tablets containing AM. The statistical data indicates the accuracy, reproducibility and the precision of the proposed methods.