PULMONARY FUNCTION DERANGEMENT IN PATIENTS OF DIABETES MELLITUS

Background: Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia resulting from defects in insulin secretion, action or both. Nonenzymatic glycosylation induced alteration of lung connective tissue is the most likely mechanism underlying the mechanical pulmonary dysfunction in diabetic subjects. The present study evaluates the impact of diabetes mellitus on pulmonary function in this cross sectional study of population. Aims and objectives: To evaluate the impact of diabetes mellitus on pulmonary functions by comparing with control groups. Materials And Method: All patients presenting in Department of Medicine, R.N.T. Medical College, Udaipur who were proved cases of type 2 diabetes mellitus were included in this study from September 2017 to September 2018. 50 patients and 50 controls with matched age and sex were included. All patients were interviewed, detailed history was taken with respect to risk factors and detailed physical examination was carried out and appropriate investigations were carried out. Results: FVC among diabetics was low with a mean of 2.46 as compared to controls with mean of 2.99 with p value of 0.001 which is statistically significant. FEV1 was reduced in cases with mean of 2.0542 compared to controls with mean of 2.4906 with a p value of 0.001 being statistically significant. FEV1/ FVC was higher in diabetic group with mean value of 0.8304 as compared with controls with mean value of 0.8316. Conclusion: Diabetic patients show reduced lung function with a restrictive pattern of lung disease on the Spirometry.