Prophylactic effect of vitamin E and coriander (Coriandrum sativum) seed extract against lead toxicity in liver of Swiss albino mice

Lead is the most abundant toxic metal in the environment that causes serious health hazards in animals and humans. In this study, the prophylactic effects of vitamin E and coriander (Coriandrum sativum L.) seed extract on lead-induced liver damage in Swiss albino mice were investigated by gross and histological studies. At first, mice were intoxicated with a particular dose of lead acetate for 42 days. After intoxication, mice were divided into three groups for treatment purpose. The first and second groups of mice were treated with vitamin E and coriander extract respectively. Both vitamin E and coriander extract were given to the third group of mice. Treatment was done for 42 days. In this study, lead acetate was found to cause nodular lesion and congestion in the central vein in liver. Vitamin E was found effective in the treatment of congestion in the central vein of liver but ineffective in the treatment of the nodular lesion. The nodular lesion was found in liver even after vitamin E treatment. The liver was found normal in the coriander extract-treated group as well as combined vitamin E and coriander extract-treated group. There was no nodular lesion as well as congestion in the central vein of liver in these two groups. The present findings revealed that lead has detrimental effects on the liver of mice. Treatment with coriander extract was found more effective than the treatment with vitamin E in lead intoxicated mice. The combined action of vitamin E and coriander extract is more effective than their individual action. The present investigation may serve as baseline data about the adverse effects of lead toxicity and efficacy of vitamin E and coriander extract against lead toxicity.