Nasal Blastoid Variant of Mantle Cell Lymphoma with Rearrangement of CCND1 and c-myc Genes with One Case Report

CCND1 and c-myc gene rearrangements are observed as a genetic change in the blastoid variant of mantle cell lymphoma, which is a rare subtype of double-hit lymphoma. Herein, we reported one case of nasal blastoid variant of mantle cell lymphoma with both CCND1/IGH and c-myc gene rearrangements in a 52-year-old man who had a solid mass in right nasal cavity. Histologically, the tumor was composed of pleomorphic medium to large-sized lymphoid cells with prominent nucleoli and active mitotic figures. Immunohistochemistry staining showed that the tumor cells were positive for vimentin, CD99, CD79a, Bcl-6, Bcl-2, CD5, cyclin D1, c-myc, SOX11 and MUM-1. Ki-67 expression was found in approximately 95% of tumor cells. Both CCND1/IGH and c-myc gene rearrangements were found in this case by fluorescence in situ hybridization. The differential diagnosis includes carcinoma, malignant melanoma, olfactory neuroblastoma, and rhabdomyosarcoma.