Formulation and In-Vitro Evaluation of Fast Dissolving Oral Film of Furosemide Using a Combination of Natural and Synthetic Disintegrant

This study attempts to formulate and characterize Lepidium sativum and synthetic disintegrant based oral films of Furosemide prepared by solvent casting method. The films were prepared using HPMC as film-forming polymer, Lepidium sativum mucilage as a natural disintegrant, Crospovidone as synthetic disintegrant, and PEG-400 as plasticizer. Furosemide is a loop diuretic that prevents our body from absorbing too much salt. It is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome and also used in high blood pressure. It has poor solubility and oral bioavailability of 60%. Furosemide was formulated as a fast-dissolving film to optimize bioavailability by solubilizing fast. Evaluation parameters such as thickness, weight uniformity, folding endurance, drug content uniformity, in-vitro disintegration time, in-vitro dissolution test, surface pH were carried out and the results were found to be satisfactory. The surface pH of films was found to be 7.8±0.5. The invitro disintegration time of optimized formulation was found to be 16.7±4.80 (n=10) seconds and in-vitro dissolution studies of optimized formulation showed a drug release rate of 79.3504% within 20 minutes.