MONO- AND MIXED-HERPESVIRUS INFECTIONS: ASSOCIATION WITH CLINICAL SYNDROMES OF IMMUNODEFICIENCY
Journal: RUDN Journal of Medicine (Vol.22, No. 2)Publication Date: 2018-07-26
Authors : I Nesterova; E Khalturina;
Page : 226-234
Keywords : herpesvirus infection; antiviral defence; interferon;
Abstract
In recent years, the number of hard diagnosed, polysymptomatic and polysyndrome conditions and diseases caused by mono- and mixed-herpes infections has sharply increased in the practice of physicians of all specialties. The clinical aspects of the close attention of physicians, virologists and epidemiologists to this viral family are due not only to the onset of atypical forms of these infections, but also to the emergence of the relative new concept of “active chronic atypical infection” caused by herpesviruses and in particular the Epstein-Barr virus. We observed 198 people of both sexes aged between 23 and 60 years, suffering from mono- and mixed herpetic infections (EBV, CMV, HSV 1/2, and HSV type 6). 36% of these, suffered from mono-herpesvirus infections, mixed-herpesvirus infections were diagnosed in 63.7% of cases. A study of functioning characteristics of antiviral protection system as well as defects and disorders in the system of interferons was carried out in patients suffering from various mono-, mixed herpes virus infections and bacterial co-infections. The main clinical syndromes associated with these herpetic infections, as well as prevailing nosological forms of concomitant diseases were revealed. The revealed clinical syndromes and functioning characteristics of an antiviral protection will allow developing of a conceptual, individualized, etio- and immunopathogenetic therapy.
Other Latest Articles
- IMMUNOGENETIC CRITERIA FOR THE DEVELOPMENT OF INFECTIOUS-ASSOCIATED FORMS OF CERVIX CANCER
- STUDY OF EXPRESSION OF HBD-1 AND HBD-2 GENES IN EPITHELIAL CELLS OF MUCOUS UPPER AIRWAY IN NEWBORNS WITH PNEUMONIA DEPENDING ON THE CAUSATIVE AGENT
- ОBJECTIVE METHOD SELECTION OF CHILDREN WITH INFANTILE HEMANGIOMAS FOR TREATMENT BY LASER RADIATION AND EVALUATION OF EFFECTIVENESS
- ASSOCIATION OF CC16 POLYMORPHISM WITH RISK FACTORS OF FORMATION OF BRONCHO-OBSTRUCTIVE SYNDROME IN CHILDREN
- ACTIVE DYNAMICS OF THE ENZYMES OF THE ANTIRADICAL PROTECTION AND THE GENERAL ANTIOXIDATIVE ACTIVITY BY THE DEVELOPMENT OF THE EXPERIMENTAL ISCHEMIC REPERFUSION OF LIVER
Last modified: 2020-09-10 05:20:01