Clinical and diagnostic value of the determinantion of fractalkine in atopic dermatitis in children

Atopic dermatitis belongs to the most common dermatoses observed in practice. In 2016 it was in 647 cases of atopic dermatitis (439,2 per 100 thousand population), while the main group of cases were children aged 0 to 14 years (64%). Aim. The aim of the study was to improve the diagnostics of allergic skin diseases in children. Materials and methods: the study included 135 children with atopic dermatitis and 29 children in the control group. Clinical and laboratory examination of patients was carried out in accordance with the standards of diagnosis of atopic dermatitis. Additionally, we determined the level fractalkine in blood serum using enzyme immunoassay kit for the quantitative determination fractalkine in biological fluids. Results. For children with atopic dermatitis regardless of clinical manifestations, characterized by elevated concentrations of fractalkine in blood serum depending on the duration of the process. Conclusions. Definition of fractalkine seems to be promising in the assessment of severity of dermatosis using it for monitoring and forecasting the further course of the process, and for assessing the effectiveness of therapeutic interventions.