Potential Anti-Inflammatory Effects of Jatropha curcas L.: A Review

Inflammation is a biological process in response to infection, injury, or irritation. The increasing incidence and impact of inflammatory diseases have encouraged the search for new pharmacological strategies to face them. Jatropha curcas L. has been traditionally used as anti-inflammatory diseases, antipyretic, and wound healing. Therefore, we aimed to present a review regarding the current knowledge of the anti-inflammatory activity of Jatropha curcas L. This review provides the evidence in the literature of the in vitro and in vivo anti-inflammatory activity of Jatropha curcas L. from 2010 to August 2020. Three bibliographical databases were used as information sources (PubMed, ScienceDirect, and Google Scholar). The search terms were "Anti-inflammatory" OR "Antiinflammatory" OR "Inflammation" AND "Jatropha curcas." A total of 9 studies were included in this paper based on our eligibility criteria with 5 in vitro studies, and 4 in vivo studies performed to substantiate the anti-inflammatory. This review has demonstrated the importance of Jatropha curcas L. as the potential for the natural anti-inflammatory. The bioactivities of Jatropha curcas L. are exhibited through the downregulation of different types of inflammatory mediators. Jatropha curcas L. has been reported to be able to inhibit the activity of nitric oxide production, reduce edema, and reduce the recruitment of neutrophils.