Antibacterial Activity of Bis(Indolyl) Methane Derivatives against Staphylococcus Aureus

In the present study, we successfully synthesized a series of indoles with a variety of aromatic aldehydes via one-pot route. The excellent results of the bis(indoly) methane (BIM) derivatives was obtained at the presence of 5.0 mol% p -toluene sulfonic acid in acetonitrile at room temperature using conventional process. All the as-synthesized compounds were bioactive. The synthesized BIM derivatives were evaluated for the antibacterial activity (in vitro) against the Staphylococcus aureus, and the results were compared with the standard Kanamycin. The results confirmed that, majority of the as-synthesized compounds revealed splendid antibacterial activity.