IMMUNOREACTIVITY OF NEUN, NEUROGLOBIN AND ATP SYNTHASE IN DEVELOPING HISTAMINERGIC NEURONS OF THE RAT HYPOTHALAMUS

Of particular interest is the study of the immunoreactivity of NeuN, Ngb, and ATP synthase in developing histaminergic neurons, since their importance and insufficient knowledge. Objective. Assessment of NeuN, Ngb, and ATP synthase content in E2 nucleus histaminergic neurons of rat brain in the dynamics of postnatal ontogenesis. Material and methods. The study was performed on 5-, 10-, 20-, 45- and 90-day old outbred white rats using immunohistochemical, cytophotometric and statistical methods. Results. In developing histaminergic neurons of rat brain the immunoreactivity of MAO B, NeuN, Ngb, and ATP synthase simultaneously increases from day 5 to 90 after birth. Conclusions. During the postnatal development of histaminergic neurons in parallel with their structural and metabolic formation, a simultaneous increase in the immunoreactivity of MAO B, NeuN, Ngb and ATP synthase.