DYNAMICS OF C-REACTIVE PROTEIN CONTENT IN PATIENTS UNDERGOING RADICAL PHLEBECTOMY ON THE LOWER LIMB

Objective. Study of the possibility of determining the content of C-reactive protein (CRP) in the blood serum of patients as a quantitative criterion of effectiveness in radical phlebectomy on the lower limb. Material and methods. The prospective non-randomized observational study involved 34 patients. To achieve this goal, patients were divided into groups: group 1 – patients with normal CRP content before surgery up to 5 mg/l (n=29); group 2 – patients with increased CRP content before surgery (n=5). The age of patients in all patients of both groups ranged from 32 to 69 years. Patients underwent radical phlebectomy on the lower limb with the removal of a large saphenous vein with varicose-expanded branches and subfascial ligation of the perforant veins. Results. At stage 1 of the study (before surgery), the serum CRP content in all patients of both groups was equal to 0.49 (0.17; 2.21) mg/l, at stage 2 (20-24 hours after surgery), a significant increase in CRP was observed, which was 13.73 (7.24; 20.19) mg/l (p<0.05). At stage 3 (44-48 hours after surgery), the CRP content significantly increased compared to stage 1 and stage 2 – 25.66 (13.69; 45.78) mg/l, statistically significant differences (p<0.05). Analysis of the dynamics of CRP in patients of two groups showed the following: the level of CRP was equal at stage 1: in group 1 – 0.39 (0.1; 1.24) mg/l, and in group 2 – 7.5 (5.39; 10.15) mg/l (p<0.05). The CRP content at stage 2 was equal to: 13.44 (7.07; 16.47) mg/l in group 1 and 22.95 (8.44; 33.05) mg/l in group 2 (p>0.05). At stage 3, the level of CRP was equal to: 23.35 (13.45; 48.85) mg / l in group 1 and 42.27 (17.14; 52.65) mg/l in group 2 (p>0.05). Conclusion. The level of CRP in the blood serum can be used as a criterion for the effectiveness of surgery in the early postoperative period.