DESIGN AND SYNTHESIS OF NOVEL TRIAZOLYL/OXADIAZOLYL/ THIADIAZOLYL-CARBAZOLES AS POTENT ANTICONVULSANT AGENTS

Compound-1, was synthesized by the reaction of carbazole with chloroacetyl chloride in dry acetone. Compound 1 on reaction with hydrazine hydrate yielded compound 2, which on reaction with various substituted phenyl isothiocyanates in absolute alcohol yielded compounds 3-8 i.e.2-(carbazolylacetyl)- N-(substituted phenyl)-hydrazine carbothioamides. Compounds 3-8, on reaction with aqueous NaOH, ethanolic NaOH and conc. H2 SO4 afforded triazoles (9-14), oxadiazoles (15-20) and thiadiazoles (21-26), respectively. The structures of these compounds were established on the basis of analytical and spectral data. Twenty four newly synthesized compounds were evaluated for their anticonvulsant activity and acute toxicity.