Effects of Siam Weed (Chromolaena odorata) Leaf Extract on Crude Oil-induced Toxicity
Journal: Galician Medical Journal (Vol.27, No. 3)Publication Date: 2020-09-28
Authors : Fidelis Ifeakachuku Achuba; Charles Offor;
Page : E20203-E20203
Keywords : crude oil; siam weed; blood; liver; kidney; oxidative stress;
- Effects of Siam Weed (Chromolaena odorata) Leaf Extract on Crude Oil-induced Toxicity
- QUALITATIVE PHYTOCHEMICAL SCREENING AND MOSQUITO REPELLENCY OF CHROMOLAENA ODORATA (ASTERACEAE) LEAF EXTRACT AGAINST ADULTS OF CULEX QUINQUEFASCIATUS (DIPTERA: CULICIDAE)
- Allelopathic Effect of Invasive Weed, Chromolaena odorata on Seed Germination and Seedling Growth of Cowpea
- Soil seed bank and mapping Chromolaena odorata an invasive weed in agro-ecosystems of Serengeti district, Tanzania
- PHYTOCHEMICAL AND ANTIMICROBIAL ANALYSES OF LEAF EXTRACTS OF CERATHOTECA SESAMOIDES AND CHROMOLAENA ODORATA
Abstract
The objective of this study was to investigate the effects of the different extractsВ (aqueous, ethanol and blended mixture) of Chromolaena odorata leaves on Wistar rats feed with crude petroleum (CP) tainted feed (4 ml/100 g diet). Materials and methods: Twenty-five male Wistar rats weighing 140 -180 g were used for this study. The rats were kept one in a cage. Group A which was the control was allowed diet free of crude oil and were not treated with any of the extracts. Group B were exposed to a diet contaminated with crude oil that contained 4ml of crude oil per 100 gram of animal feed without treatment. Groups C-E were fed with diets contaminated with 4ml of crude oil per 100g of feed and treated with 500mg/Kg-1 bodyweight of aqueous, ethanol and blended mixture of ethanol and aqueous extracts, respectively. The respective extracts and blended mixture were given daily to the rats via oral gavage in line with body weights. The study was for duration of twenty eight days after which the rats were sacrificed under sedation with chloroform. This was followed with collection of blood samples and organs of interest. All samples were stored at 40C and used within forty eight hour for various biochemical analyses. Results: There were significant decrease in haematological indices, liver proteins, oxidative enzymes, В and antioxidant enzymes when compare withВ Group 1. Also, liver function maker enzymes, white blood cells (WBC), and malondialdehyde (MDA) В В were significantly increased В by petroleum intoxication. Significant increase were observed in Hb, PCV, RBC, SO, MO, XO, SOD, CAT, albumin, total protein in the serum, liver and kidney; as against decreases in WBC, AST, ALT, ALP and MDAВ in rats fed crude petroleum (CP) tainted feed that was treated with C. В odorata extract.В Conclusion: This study showed that administration of C. odorata leaves extracts to rats prevented health risk associated with crude petroleum toxicity.
Other Latest Articles
- Study of the Association Between Antihyperglycemic Therapy and Cancer in Patients with Type 2 Diabetes Mellitus
- Assessment of Relationship Between Nutritional Status and Handgrip Strength in Hemodialysis Patients
- Impact of Periodontal Pocket Depth on the Efficiency of Surgical Treatment of Generalized Periodontitis
- Role of Diffusion-Weighted and Chemical Shift Magnetic Resonance Imaging in Differentiation of Benign and Malignant Spinal Fractures
- About Some Aspects of Teaching Foreign Students in the Discipline "History of Medicine"
Last modified: 2020-10-30 23:29:40