ResearchBib Share Your Research, Maximize Your Social Impacts
Sign for Notice Everyday Sign up >> Login

UV SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF PALBOCICLIB IN BULK AND IN-HOUSE CAPSULE FORMULATION

Journal: Indian Drugs (Vol.57, No. 08)

Publication Date:

Authors : ; ; ;

Page : 35-40

Keywords : * For Correspondence: Email: anandmundadarcp@gmail.com;

Source : Downloadexternal Find it from : Google Scholarexternal

Abstract

Four different simple, accurate and precise UV-spectrophotometric methods have been developed for the estimation of palbociclib (PB) in bulk and in-house capsule dosage form by zero order (Method I), zero order AUC (Method II), ‘first order derivative UV-spectrophotometric (Method III), and first order AUC (Method IV) methods. The drug was dissolved in methanol (AR-Grade) and further dilution was made in double distilled water. Zero order was performed at λ max 220.00 nm of PB (Method I) and AUC was calculated between 215.40 nm - 228.20 nm wavelength (Method II). In Method-III zero-order spectra were derivatized into first-order and amplitude measured at 231.00 nm and the AUC was recorded between 224.00 nm - 240.60 nm (Method IV). PB followed linearity in the concentration range of 4.08-20.40 µg/mL with correlation coefficient (r2 )> 0.99 for PB.

Last modified: 2020-11-10 14:03:06