Interconnection of Psoriasis with kidney disease: A Traditional Review

Psoriasis is characterized by abnormal hyperproliferation of keratinocytes with dysfunction in immune regulation. It has been postulated that psoriasis is a systemic entity rather than a solely dermatological disease The prevalence of chronic kidney disease (CKD) and end-stage renal disease (ESRD) are surging, and they have become a global health problem causing considerable morbidity and mortality worldwide. Kidney injury is defined as an anatomical alteration of the organ or the presence of proteinuria or hematuria. The exact mechanisms underlying the link between psoriasis and renal dysfunction remains not entirely understood. Many pathogenetic mechanisms are thought to be shared by psoriasis and End-stage renal disease like increased levels of cytokines, reactive oxygen species, impaired immune system leading to immune-mediated damage, and effect of drugs used to treat psoriasis leading to drug-induced damage to kidneys. The development of chronic renal failure in psoriasis seems to be connected to the chronic inflammatory state that causes a steady decline of all organs. A growing body of literature indicates the role of Th17 immune response in both renal inflammatory diseases and psoriasis. In this comprehensive review article, we will try to enlist and describe possible ways in which the linkage of psoriasis and kidney damage can be explained by exploring currently available literature from PubMed.