Features of Folliculogenesis and Endometrium Condition in Patients with Hypothalamo-Hypophyseal Dysfunction

The paper aims at identifying the features of folliculogenesis and endometrium condition in patients with hypothalamo-hypophyseal dysfunction and optimizing the surveillance tactics of this contingent of gynecologic patients. Material and methods. We examined 180 women who suffered from infertility. They were divided into tree clinical groups: Group I – 111 patients with hypothalamo-hypophyseal dysfunction without ovulation induction performed; Group II – 36 patients with hypothalamo-hypophyseal dysfunction with ovulation induction performed once or more using Clostelbegyt in an individually determined dose from the 5th to 9th day of the menstrual cycle, the 2nd phase of the menstrual cycle was supported by Progesterone or its analogues; Group III – “control” group – 33 patients with no hypothalamo-hypophyseal dysfunction diagnosed according to the results of clinical and laboratory studies (including assessment of the hormonal profile). Results and discussion. The condition of follicular growth and maturation, occurrence of ovulation, changes in the endometrium were assessed from the 9th day of the menstrual cycle applying real-time ultrasonic method by sector 3.5 MHz transducer with Sonoline SL-1 (Germany). The following factors were taken into account for the analysis: the thickness and structure of the endometrium, its conformity with the phase of the cycle; diameter, number of follicles; occurrence of ovulation and the day it occurs; persistence or atresia of the follicle; frequency of conception in the studied menstrual cycle during the 1st year after surveillance. Statistical processing is performed using the package of statistical software Excel 7.0 using parametric and nonparametric methods of analysis. Conclusions. The revealed features of folliculogenesis and endometrium condition both in patients with hypothalamo-hypophyseal dysfunction, and in women without endocrine disorders, should be taken into account when conducting ultrasonic monitoring of folliculogenesis and in the analysis of the ovulation induction effectiveness.