The Influence of Chronic Alcohol Intoxication on Blood Biochemical Indicators in Mechanical Treatment

Alcohol intoxication leads to an increase in both somatic diseases and mechanical injuries and becomes not only a medical but also a social problem. The importance of this problem is also connected with the fact that half of the deaths are made up of people of working age from 20 to 60 who were in the state of alcohol intoxication. A sufficiently large number of persons with chronic alcohol intoxication are among them. The purpose of the study was to develop a set of criteria to evaluate the effects of chronic alcohol intoxication on the morpho-functional state of the internal organs (liver and pancreas) with mechanical trauma biochemical blood indices. Material and methods. Research materials are medical records of 74 inpatients and ambulatory patients with chronic alcoholism, who appealed for help to the regional drug treatment clinic and 116 medical records of injured inpatients and ambulatory patients who applied to hospital. We used the following biochemical methods: a) blood chemistry: study of total protein, alanine aminotransferase, aspartate aminotransferase, glucose, cholesterol, total, direct and indirect bilirubin, alpha -amylase , b) forensic blood chemistry, urine for alcohol content. Results and discussion. The obtained results showed that the best biochemical indicators to assess the functional state of the liver, which suffers the most under the influence of chronic alcohol intoxication is alaninaminotransferase, aspartataminotransferase, total and direct bilirubin, which significantly raised during abuse of alcohol. Pathology of the pancreas was studied by the enzyme α-amylase, which were raised because of alcoholic and traumatic injuries. The biochemical parameters of blood in men were statistically significantly different among all the groups under study (p <0.05). The first group consisted of men who died not brutally though they had chronic alcohol intoxication; the second comprised the men who died from mechanical trauma having the chronic alcohol intoxication; the third – men who brutally died from a mechanical trauma. The most statistically significant differences are the characteristics of AlAT, AsAT, general and direct bilirubin, which are significantly higher in the injured men who did not drink alcohol than in men with chronic alcohol intoxication, and in men who received a mechanical injury being in the state of alcohol intoxication. In the course of the study, we found that the biochemical parameters of blood in women were statistically significantly different among all the groups under study (p <0.05). The first group consisted of women who died not brutally though they had chronic alcohol intoxication; the second comprised the women who died from mechanical trauma having the chronic alcohol intoxication; the third – women who brutally died from a mechanical trauma. The most statistically significant differences were characterized by indicators of AlAT, AsAT, general and direct bilirubin, which were significantly higher in injured women who did not drink alcohol than in women with chronic alcohol intoxication and in women who received mechanical injuries being in the state of alcohol intoxication. In the course of our research and static treatment of biochemical blood parameters using the method of multidimensional statistics (binary logistic regression method), we established the possibility of predicting the presence of chronic alcohol intoxication in the dead and those who died from mechanical trauma.