Changes of the Citokinate Status Parameters on the Basis of Determination of Activity of Calprotectin and Interleukin-22 in Patients with Acute Myocardial Infarction with Diabetes Mellitus Type 2

The purpose of the study was to evaluate changes in the pro-and anti-inflammatory parameters of the cytokine status based on the determination of the activity of calprotectin and interleukin-22 in patients with acute myocardial infarction, depending on the presence or absence of concomitant type 2 diabetes, as well as to analyze the relationships between cytokinemia and carbohydrate metabolism in the studied cohorts of patients. Material and methods. A total of 110 patients (mean age 65.25±0.09 years) who were on treatment in the infarctional department of Kharkiv city clinical hospital №27 and Kharkiv clinical hospital on railway transport №1 were examined. 64 patients (average age 65, 31±1.62 years) for acute myocardial infarction with concomitant type 2 diabetes mellitus. The comparison group was 46 patients with isolated acute myocardial infarction (mean age 65.19±1.22 years). Results and discussion. Blood glucose concentration was determined by glucose oxidase method. Determination of the level of insulin was carried out using the immunoassay method using the test system EIA-2935, Insulin ELISA. Determination of serum calprotectin level was performed by immunoassay using the MRP8 / 14 ELISA KIT test system. Determination of the level of interleukin-22 serum was carried out by immunoassay using the human IL-22 ELISA KIT test system. Conclusions. The resulting linkages between calprotectin and IL-22 in patients with isolated acute myocardial infarction indicate a high activity both pro- and anti-inflammatory levels of cytokine status. In patients with acute myocardial infarction type 2, the hyperactivity of the proinflammatory indicator of calprotectin was associated with a decrease in anti-inflammatory IL-22, which proved that there was no compensatory reaction in this cohort of patients.