PROGNOSTIC AND DIAGNOSTIC VALUES OF ACUTE PHASE PROTEINS (APPs) AND ULTRASONOGRAPHY IN EXPERIMENTALLY INDUCED BACTERIAL CYSTITIS IN DOGS

The aim of the study is the further use of ultrasound and acute phase proteins in diagnosis of bacterial cystitis in dogs. The present research was performed on 15 dogs apparently healthy, their weight were ranged from 20±0.5 Kg BW. Divided into 2 groups, Group (1): contained 10 dogs subjected to experimentally induce bacterial cystitis by pathogenic strains of Staphylococcus aureus and Group (2): contained 5 dogs act as control group. The diseased dogs showed inappetance, abdominal pain, pollakiuria, stranguria, arched back, lethargy and depression, compared to the control group which was were very active, in good physical condition and had normal appetite. The biochemical alteration included no significant change in kidney functions as serum creatinine, BUN and uric acid. Significant increase in serum haptoglobin, SAA from the 3rd day after induction till the end of experiment. There is significant decrease in serum total protein and albumin from the 3rd day till the end of experiment, com-pared to the control group. Urine analysis illustrated alkaline pH, negative glycosuria, and proteinuria, compared to the control group. Ultrasound imaging showed increase of bladder wall echogenicity, de-crease in circumscribed anechoic area represented the urine which appear hyperechoic and contain suspended material which represents cellular debris, irregular bladder mucosa these changes at the 3rd day till the 15th day, compared to the control group. Macroscopic findings of dogs' urinary bladder showed diffuse thickening of the bladder wall and haemorrhage of dogs with induced bacterial cystitis. Microscopically, urinary bladder showed destruction and desquamation of transitional epithelium in the lumen of the urinary bladder. The lamina propria and submucosa showed haemorrhages and congested blood vessels.