METHODS OF ASSESSMENT OF THE QUALITY OF LIFE OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

Systemic lupus erythematosus (SLE) is one of the most serious human autoimmune diseases, affecting almost all organs and systems. The quality of life of patients with SLE remains lower than the population level. Thanks to the assessment of quality of life, the patient can be assessed holistically, taking into account emotional and mental well-being, as well as socio-economic factors. Assessing the QOL of a patient with SLE facilitates the planning of patient care and ensuring an appropriate relationship between physician, physical therapist, occupational therapist, and patient. The publication presents modern approaches to assessing the quality of life (QL) of patients with systemic lupus erythematosus (SLE) and critical analysis of methods for assessing disease activity, general and spe-cific questionnaires that most objectively reflect the pa-tient's condition. The presented publication is a narrative review. The data were searched in a database of articles in the field of medicine and biology at the PubMed Na-tional Center for Biotechnology Information (NCBI) and the Google Scholar Search Engine. The analysis of the literature showed that SLE significantly worsens patients' QL. The main key triad of problems that cause worsening of QL has been identified in SLE patients - fatigue, pain, and depression. The usefulness of common QL question-naires in patients with SLE are not fully studied, but most authors recommend the use of a common questionnaire - SF-36 (validated in Ukraine) as a "gold standard". Among 60 activity indexes of SLE, only five have been validated and are widely used in the world of medical treatment and scientific practice - SLE Disease Activity Index (SLEDAI); Systemic Lupus Activity Measure (SLAM); European Consensus Lupus Activity Measure-ment (ECLAM); Lupus Activity Index (LAI); Classic British Isles Lupus Assessment Group Index (Classic BILAG Index). These special for SLE QL questionnaires are sufficiently sensitive to this nosology, and take a short time to respond. Their use depends on the patient's request and the goals he or she sets (T2T – treat to target). In these cases, it would be advisable to use LupusPRO. In SLE-QoL more attention is paid to physical functioning, treatment, mood, self-image, in L-QoL - to self-care, fatigue, emotional reactions, in Lupus QoL - physical health, pain, intimate relationships, emotional health, body image, fatigue. Some questionnaires are used at low and medium activity index - LUP-QoL, others - at high. And in a questionnaire like LupusPRO, does not mention of the SELENA-SLEDAI index and the SLICC / ACR VP. The questionnaire will be effective if applied ra-tionally in each case. Awareness of the change in results, reported by the patient, about clinically relevant changes in the course of SLE, is critical to managing a personal-ized illness. It is important that the questionnaire is vali-dated and adapted to the specific country. Special QL questionnaires for SLE patients need to be validated in Ukraine.