INTEGRAL ESTIMATION OF ENDOGENOUS INTOXICATION OF ORGANISM IN PROGNOSTICATION OF THE FLOW ACUTE APPENDICITIS IN CHILDREN

Exactness of diagnostics of acute appendicitis remains an important problem of modern clinical surgery of child's age. Diagnostics of acute appendicitis in children is complicated by considerable anatomic differences and physiological features of the child's organism, which leads to delay of terms of surgical treatment and in accordance with an increase risk of development of complications. In addition, the differential diagnostics of pathological processes that simulate acute appendicitis, on occasion shows a large problem, especially for the children. The article is devoted to research of blood analysis in the different forms of acute appendicitis on the basis of study of indexes of endogenous intoxication in organism. Endogenous intoxication is caused by an accumulation in the blood toxiferous substances in concentrations, that exceed functional possibilities of the natural detoxication systems with the damage of other organs and systems of organism. The integral estimation of endogenous intoxication in humans organism is executed by mathematical method and consists of two indexes of intoxication. The first index (index of correlation of leucocytes and erythrocyte sedimentation rate) estimates general white blood cell count in blood and erythrocyte sedimentation rate. The second index (index of change of leucocytes) estimates the level of eosinophils, basophilies, all forms of neutrophils, lymphocytes and basophilies). If unite these indexes in one integral (total index of intoxication), then a result of estimation of intoxication of organism will be more precisely. The total index of intoxication estimates all indexes of general blood analysis that is appropriate in cases with suspicion on acute appendicitis. In our research we conducted an examination of 400 children with suspicion on acute appendicitis. Middle age of patients was 12,6±1,2. As a result of research considerable differences were found in the indexes of correlation leucocytes with erythrocyte sedimentation rate and index of change of leucocytes. The aim of our work was the development of total index of intoxication, that is estimates the more factors of blood test, than two previous separately. After the count of total index of intoxication it is possible more exactly to estimate the level of intoxication in organism at acute surgical pathol-ogy. Increase of total intoxication index more than in 2,5 times characteristic for the destructive forms of acute appendicitis. Introduction of total intoxication index in the algorithm of acute appendicitis will allow to improve the results of early diagnostics of pathology and its mo-tion in children. At the complicated motion of acute ap-pendicitis an infection is one of the main reasons in an origin and development of endogenous intoxication, the level of that is related to weight of tissue destruction. Integral approach of interpretation of indexes of endoge-nous intoxication from data of blood test on the basis of level of total index of intoxication allows to estimate expressiveness of endotoxemia. By a positive line, we have developed the total index of intoxication is simplic-ity and speed of counting. For the calculation of this index it is necessary only results of general analysis of blood. For greater simplification of calculation of index it is possible to use the personal computer with Ms Office software or calculator.