ON THE EVALUATION OF THE SIGNIFICANCE OF HYPERURICEMIA FROM THE POSITION OF BELONGING TO THE METABOLIC SYNDROME

Purposes: analysis of the relationship of hyperuricemia with the components of the metabolic syndrome in a random population sample. Methods. The group of subjects (n = 727) was formed according to the generally accepted epidemiologi-cal approaches by the method of random sampling from among the workers and employees of the industrial enter-prise Private joint-stock company «Novokramatorsky machine-building plant». The age of the subjects ranged from 18 to 65 years, the average (38.13 ± 5.1) years. The presence and degree of obesity were determined by body mass index, according to WHO criteria 2000. Determina-tion of waist circumference (cm) was performed in the vertical position of the patient in the middle of the dis-tance between the lower edge of the chest and the crest of the Ilium along the mid-inguinal line. Metabolic syn-drome was diagnosed according to a joint intermediate statement IDF, NHLBI, AHA, WHF, IAS and IASO. Diagnosis of disorders of glucose homeostasis was carried out according to the recommendations of ADA, 2012. Conducted clinical and biochemical researches (anthro-pometric parameters and blood pressure, immunoreactive insulin levels, lipid profile, uric acid concentration in the blood), the degree of severity of insulin indifference HOMA2_IR. Statistical analysis was performed using "Statgraphics Plus for Windows 3.0". The normality of the distribution of variables was determined using the Shapiro-Wilk test. The Wilcoxon-Mann-Whitney test was used to compare paired variables in groups with normal distribution of variables. The "Chi-square" (χ2) criterion with Yates correction was used for statistical estimation of differences between the empirical and theoretical fre-quencies of the variation series. Regression analysis was used to identify the relationship between clinical, bio-chemical, and hormonal indicators and the normal distri-bution of variables. Results. Hyperuricemia was diagnosed in 16.2 % of people. It has been established that in people with hyperuricemia the probability of diagnosis of disorders of glucose homeostasis increases by 5.1 times, diabetes mellitus by 3.7 times, obesity by 2.9 times, hypertension – high blood pressure by 2.3 times and dyslipidemia by 1.7 times, respectively. It is determined that almost every second case of hyperuricemia in a random population sample is associated with at least two more components of metabolic syndrome (high blood pressure + obesity), in every fourth case – with three components (high blood pressure + obesity + dyslipidemia), in every eighth case – with four components (hypertension + obesity + dyslipidemia + disorders of glucose homeostasis). It was found that in every fourth representative of the random population sample, who was diagnosed with impaired glucose tolerance and type 2 diabetes mellitus, has a "complete" metabolic syndrome; the probability of diag-nosing metabolic syndrome in people with disorders of glucose homeostasis increases 10 times compared with the population. Conclusions. If the verification of "complete" metabolic syndrome is not limited to the mandatory inclusion of hyperuricemia, the frequency of diagnosis in one member of a random population sample of the quartet of symptoms (obesity + high blood pressure + dyslipidemia + hyperinsulinemia) doubles and is already 4% of the total random population sample. Under this condition, every second representative of the random population sample of impaired glucose tolerance is diagnosed with "complete" metabolic syndrome.