MORPHOLOGICAL CHANGES IN WISTAR RAT FETUSES FROM PROGENITORS WITH SUCROSE-INDUCED METABOLIC SYNDROME

Women exhibiting the components of metabolic syndrome before the pregnancy have a high risk of fetal placental dysfunction, even fetal death. Moreover, glucotoxicity has been linked to birth defects. These issues have motivated checking the possible association between a metabolic syndrome and morphological damages in the conception product. In this paper, morphological alterations produced on the fetus by the metabolic syndrome of progenitors were determined in an experimental model. The bio-model was developed in Wistar rats by supplying them with 35 % sucrose from the intrauterine stage up to eighteen weeks of age. Subsequently, crossing was performed, the pregnancy was confirmed, and blood pressure was checked. Two groups of pregnancy were formed; metabolic syndrome and healthy control. Cesarean section was performed on day twenty of gestation, in order to make the corresponding first segment studies of reproductive toxicity. Maternal parameters such as body and organ weight were assessed. Weight, crown-rump length and total number of fetuses by group, as well as skeletal and soft tissue of the fetuses were recorded. Hematoma was the main external change found, as well as there was significant decrease in fetuses' weight of metabolic syndrome parents' group. In these fetuses, the absence of Xiphoid and Sterne brae was reported as the principal developmental delays in bone tissue and no noticeable damage was observed in soft one. These results suggest that the metabolic syndrome morphologically affects the conception product.