Interleukin-6 in Saliva & GCF Level after SRP in Chronic Periodontitis with & without Type 2 Diabetes Mellitus

Background: Diabetes and periodontitis are common chronic diseases and epidemiological evidence implies a two-way relationship between the two diseases. Cytokines in saliva and gingival crevicular fluid (GCF) increased in chronic periodontitis with and without type 2 diabetes mellitus (T2DM) are associated with increased inflammation of periodontal tissue. Type 2 diabetes mellitus can worsen the periodontal condition, while periodontitis can also worsen glycemic control. Scaling and root planing (SRP) can improve glycemic control and reducing mediators of inflammatory cytokines such as interleukin-6 (IL-6). Aim: To analyze comparison clinical parameters (Papillary Bleeding Index, Gingival Index, Pocket Depth, Clinical Attachment Loss), IL-6 level in saliva and GCF before and 2 weeks after SRP in chronic periodontitis patients with and without T2DM. Methods: The study design was pre and post-test with samples of 15 subjects with chronic periodontitis with T2DM (CP + T2DM) and 15 subjects with chronic periodontitis (CP). Results: There was a significant reduction in clinical parameters, IL-6 level in saliva and GCF after SRP in periodontitis patients with and without T2DM. Only PBI has a significant difference in clinical parameters changes after SRP between CP and CP+T2DM group. No significant difference in IL-6 level in saliva and GCF after SRP between chronic periodontitis patients with and without T2DM.