Review on: Nanoneedle Based Intracellular Delivery of Drugs & Other Biomolecules

T— Nanoneedle is widely used nowadays to deliver drugs specially which contains nanoparticles. Besides, nanoneedle is also used to deliver probes, genes, proteins, DNA, RNA, peptides, vaccines etc. The delivery of drugs & biomolecules into living cells can provided by a nanoneedle with high spatiotemporal resolution, minimal damage. Thus, it become painless and noninvasive. Accessing the interior of live cells with minimal intrusiveness for visualizing, probing, and interrogating biological processes has been the ultimate goal of much of the biological experimental development. Current aim of research is to summarize the types, vehicles, materials, fabrication, advantages & future developments of nanoneedles. To serve the knowledge about recent development of nanoneedle based intracellular delivery. To review the wide applications of this new nanotechnology-based tool in the biological field, especially on its use for high-resolution studies of biological processes in living cells. All of the articles have searched from previous four months (April, 2020-July, 2020) and this articles are searched from various database including PubMed, MEDLINE, Sci-hub, Google scholar, THE LANCET etc. In this review, several important topic are discussed based on nanoneedles. These are:Nanoneedle based drug delivery vehicles, Material composition of nanoneedles, Nanoneedle arrays for intracellular delivery, Nanoneedle based drug delivery system, and Application of nanoneedle based delivery, Future Development nanoneedle based drug delivery. This study provides a comparative analysis of intracellular delivery using nanoneedles. Nanoneedles as new class of nanomaterial can influence molecular or cellular delivery of drugs & other biomolecules. Overall, this study identified key operating parameters and determined their effects on intracellular delivery and cell viability due to cell puncture using nanoneedles.