In Vivo Effects of Mondia Whitei ‗Mukombero‘ on Testicular Tissue Changes in Male Wister Rats

— In Africa, Mondia Whitei is popularly used medicinal plant to cure sexual dysfunctioning and there is still little empirical data existing in support of its therapeutic value. The main target of this research was to discuss how aqueous extract of Mondia Whitei affects testicular tissue when graded dose is administered orally brings changes in male Wister rats. Thirty-six male rats, albino weighing between 200mg -400mg were put into four groups consisting of nine rats each. There was no treatment of the rats in the first group unlike the second, third and the fourth groups, weighing 100,200 and 400mg respectively were given the aqueous extract of Mondia Whitei orally. The testes and epididymis were the examined after sacrificing the rats humanely using carbon dioxide narcosis. The testes and epididymis were studied. The gonadal tissue from the treated groups exhibited low sertoli cells in the seminiferous tubules and a thin germinal epithelium. There was degeneration of leydig cells within the interstitium and clamping of spermatozoa in the epididymis in relation to increase in extract concentration and duration. This study concludes that Mondia Whitei may be beneficial only at low dose and short duration but may alter male fertility if taken over a long time and also high doses. Therefore, Mondia Whitei can even be toxic to cells.