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Journal: Journal of the Grodno State Medical University (Vol.18, No. 6)

Publication Date:

Authors : ; ;

Page : 648-654

Keywords : ATP synthase; mitochondria; oxidative phosphorylation; brain;

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In the following review we collected and analyzed the currently available data on the structure and organization, localization, working mechanisms and functions of a universal and unique in its characteristics enzyme of ATP synthesis – ATP synthase. In addition to synthase and hydrolase activity, associated into dimers mitochondrial ATP synthase is responsible for “bending” the inner membrane of mitochondria. A large number of diseases, including neurodegenerative and mitochondrial ones, are associated with ATP synthase disorders, and among other things they are accompanied by structural changes of mitochondrial cristae.

Last modified: 2021-01-26 16:03:51