MITOCHONDRIAL ATP SYNTHASEJournal: Journal of the Grodno State Medical University (Vol.18, No. 6)
Publication Date: 2020-12-31
Authors : Uzlova E. V.; Zimatkin S. M.;
Page : 648-654
Keywords : ATP synthase; mitochondria; oxidative phosphorylation; brain;
In the following review we collected and analyzed the currently available data on the structure and organization, localization, working mechanisms and functions of a universal and unique in its characteristics enzyme of ATP synthesis – ATP synthase. In addition to synthase and hydrolase activity, associated into dimers mitochondrial ATP synthase is responsible for “bending” the inner membrane of mitochondria. A large number of diseases, including neurodegenerative and mitochondrial ones, are associated with ATP synthase disorders, and among other things they are accompanied by structural changes of mitochondrial cristae.
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