Review: Multi-Component Crystals: Cinnamic Acid As A Co-Former

Each drug compound has a different level of solubility. The active pharmaceutical ingredient (API) solubility in water is one of the critical parameters in the biological activity of drugs. To overcome this problem, it can use multi-component crystals with a cinnamic acid co-former to improve drugs' physicochemical properties because it is necessary to look for information on how to manufacture multi-component crystals. Data resources were collected from Google Scholar, PubChem, Researchgate, and all available literature from 2000-2020. This review aims to examine the effect of multi-component crystals using a cinnamic acid co-former on drugs' physicochemical properties in terms of their solubility. Several methods used in the manufacture of multi-component crystals are solvent evaporation, slow cooling, solvent drop grinding, solution cocrystallization, and liquid-assisted grinding. The results show that multi-component crystals using cinnamic acid co-former can improve the physicochemical properties of drug inactive compounds carbamazepine, itraconazole, ibuprofen, moxifloxacin, isoniazid, and lovastatin. So it can be concluded that the active substance formed with multi-component crystals using a cinnamic acid co-former effectively improves the active substance's solubility.