Genetic Aspects of Celiac Disease in Association with Pancreatic TumorsJournal: International Journal of Celiac Disease (Vol.2, No. 3)
Publication Date: 2014-09-30
Authors : Pavel Proch;
Page : 93-96
Keywords : celiac disease; pancreatic tumors; HLA-DQ2 gene locus; DQ8 gene locus; KRAS; BRCA1/2;
Celiac disease stands out as a major health problem with a frequent association with many other disorders. Studies show an increased risk of developing pancreatitis and after that pancreatic cancer in patients with celiac disease. A frequent occurrence and a remarkably close association with the HLA-DQ2 and/or DQ8 gene loci represent main genetic characteristic of celiac disease. A particular association was found with chromosome 15q26 and 6q21-22. On the other hand pancreatic tumors are known for associations with CTNNB1, VHL, CDKN2A, KRAS, TP53, RNF43, SMAD4, GNAS, PRSS1, ATM, BRCA1, BRCA2, PALB2, STK11 and hereditary non-polyposis colorectal cancer syndrome genes. Recent genetic mapping suggests that a large field of opportunities exists for better understanding of both diseases.
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Last modified: 2014-11-13 12:14:52