Bioactive Compound from Streptomyces sp. KB1 TISTR2504 as Effective Disinfectant against Microorganisms

A host environment cleaning using disinfectants is the most effective way to prevent the pathogen's transmission. This study compared the activity among of commercial liquid disinfectants [3% hydrogen peroxide (HP), and 70% ethyl alcohol (EA)] and bioactive-compounds (BCs) from Streptomyces sp. KB1 on indicating microorganisms: Bacillus subtilis ATCC 6633 as representative of spores; Staphylococcus aureus TISTR 517 and clinical methicillin-resistant S. aureus as representative of gram-positive bacteria, Escherichia coli TISTR 887, Pseudomonas aeruginosa TISTR 1467, and extended spectrum beta-lactamase (ESBL)-Klebsiella pneumoniae 342 as representative of gram-negative bacteria; Candida albicans TISTR 5779 as representative of yeast. Results showed that B. subtilis spores are resistant to 70% EA and BCs from strain KB1—which are biocidal to TISTR strains and clinical isolate MRSA, ESBL—in the free floating microorganism (suspension test). On the other hand, this resistance was not observed with 3% HP. Thus, 3% HP showed more promise for disinfecting microorganisms than that 70% EA and BCs. However, BCs did show the antimicrobial activities equal as 70% EA. The results might be implied that the using of BCs from selected bacterial strain as effective disinfectant against microorganism, especially vegetative cell, is a sustainable application in nearly future, to reduce using the chemical substances and zero wastes.