Relationship between Vitamin-D Receptor Gene Polymorphism FokI and Fetuin- A as A marker of Vascular Calcification in Egyptian Hemodialysis Patients
Journal: International Journal of Medical Arts (Vol.3, No. 1)Publication Date: 2021-01-01
Authors : Fatma Ibrahim Mayah; Hayam Hamza Mansour; Ragaa Ramadan Mohamed; Nadia Kamal Marey; Khaled Younis Younis Mohammed; Amr Mohamed Ibrahim; Tarek Fakhr Eldeen Osman;
Page : 967-975
Keywords : vascular calcification; Vitamin D receptor polymorphism; FokI; Fetuin-A; Parathormone hormone;
Abstract
Background: Vascular calcification is a common complication in end-stage renal disease patients and the leading cause of morbidity and mortality.
Aim of the work: The current work aimed to evaluate the possible relationship between vitamin D receptor gene polymorphism FokI with fetuin-A and intact parathormone hormone in Egyptian hemodialysis patients.
Patient and Methods: This study is a cross-sectional study including 50 hemodialysis patients attending the hemodialysis unit in Al-Zahra University Hospital and 30 apparently healthy persons as a control group. For all studied subjects, a detailed history was taken, physical examination, carotid intima-media thickness by carotid duplex, echocardiography, Laboratory investigations included serum levels of calcium, phosphorus, iPTH, fetuin, and genotype frequency by PCR
Results: There was a highly significant increase in carotid intimal media thickness in the patient group Vs. control group & a highly significant decrease in serum Fetuin-A in the patient's group Vs. control group. There was a significant difference in the genotype distribution of FokI polymorphism among patients and control. There were significant negative relationships between FF genotype and iPTH and a highly significant negative correlation between serum fetuin-A and iPTH in the patient group.
Conclusion: Vitamin D receptor gene FokI polymorphism FF genotyping is more frequent in hemodialysis patients who have higher iPTH and lower fetuin-A levels, which could identify the high-risk group susceptible to vascular calcification in hemodialysis patients. Further studies are needed.
Other Latest Articles
- Value of Intraoperative Ultrasound in Decreasing Incidence of Residual Radiolucent Stones Post- Percutaneous Nephrolithotomy
- Unintentional Poisoning among Preschool Children in Jeddah, Saudi Arabia (2014-2016): A Retrospective Cohort Study
- Comparative Study of Color Doppler Imaging in Normal and Abnormal First Trimester Pregnancy
- A comparison between the Use of Chest X-ray and Lung Ultrasound in the Diagnosis of Pneumonia in Children in Damietta Governorate
- Effect of Oral Exposure to Bisphenol A on the Liver and Kidney of Adult Male Albino Rats
Last modified: 2021-02-28 20:00:42