Development of Nano-structured Lipid Carriers Loaded with Corosolic Acid: An Efficient Carrier for Anti-diabetic Effects

The aim of the present study was to develop a stable Nano-structured Lipid Carriers (NLCs) of Corosolic acid to improve its oral bioavailability. Corosolic acid is water insoluble, lipophilic, and highly permeable resulting in its incomplete and variable bioavability. Thus, a suitable formulation is highly desired to enhance the aqueous solubility and dissolution rate of corosolic acid to obtain faster onset of action, minimize the variability in absorption and improves its overall oral bioavailability. NLCs of Corosolic acid were formulated by solvent diffusion method technique after lipid screening tests by using central composite design. The formulated NLCs were characterized for Mean Particle size, Transmission electron microscopy, in-vitro drug release study. It was revealed that the average size of NLCs was found 201.4±1.2nm, TEM was found 200nm. In-vitro release determined by dialysis bag diffusion technique was found 70% at the end of 6 hr. The result of the studies was concluded that Corosolic acid was successfully in corporate into NLCs by Solvent diffusion method with high entrapment efficiency, so NLCs can be demonstrated as a potential carrier to improve oral bioavailability of Corosolic acid.