Effects of Gongronema latifolium Leaf Extract on Malondialdehyde Concentration of Wistar Rats Administered With a Toxic Dose of Ibuprofen

Aim: To determine effects of Gongronema latifolium leaf extract on Malondialdehyde (MDA) levels of wistar rats induced by a toxic dose of Ibuprofen. Material and Methods: Thirty wistar rats were randomly divided into five groups with six rats in each group (n=6); Control (C) received normal feed only. T1 was administered with Gongronema latifolium leaf extract 50 mg/kg BW+ Ibuprofen, T2: Gongronema latifolium extract 100 mg/kg BW+ Ibuprofen, T3: Gongronema latifolium leaf extract 150 mg/kg BW+ Ibuprofen. T4: received Jbruprofen only.This lasted for fourteen days. On the 15th day, blood samples were collected and the level of MDA was then measured. Results: T1, T2, T3 showed significantly decreased MDA levels when compared with theT4 at p < 0.05. Conclusion: Gongronema latifolium extract has an antioxidant effect on the prevention of elevated MDA levels.