Synthesis, Characterization and Biological Studies of Cu2+, Ni2+, Cd2+, and Pt4+ Complexes Derived from 3-(3H-1,2,4-Triazole-4-(5H)-Ylimino)Butane-2-One-Oxime (L)

Novel Cu2+, Ni2+, Cd2+, and Pt4+ complexes derived from 3-(3H-1,2,4-triazole-4-(5H)-ylimino)butane-2-one-oxime (L) were synthesized and characterized. FTIR spectra propose that L acts in different methods (bi- tri- and/or tetradentate) depending on the metal used. Electronic spectra and magnetic measurements of the complexes suggest a structure that is tetrahedral for Ni2+, octahedral for Cd2+, while square-planar for Cu2+ and Pt4+ complexes. Density functional theory (DFT) parameters were applied for Cu2+, Ni2+, and Pt4+ complexes which prove the geometry of L towards the metal ions. Coats-Redfern and Horowitz-Metzger methods were used to calculate the kinetic and thermodynamic parameters of the isolated complexes. The cyclic-voltammogram curve of the Cu2+ complex was reported. The biological activity of L and its complexes were tested against three types of cancer cell lines, and against different bacterial strains.