Anti-Inflammatory Properties of Coriandrum Sativum L.: A Review

Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Natural products are a rich source for the discovery of new drugs because of their chemical diversity. The conventional drug available in the market to treat inflammation produces various side-effects. Coriandrum sativum L. is used in many countries as a traditional medicine to treat disorders of the digestive, urinary, and respiratory systems, as well as diabetes, inflammation, and other conditions. however, their important role in anti-inflammatory activity have not been fully explored. The present review is directed towards the compilation of the research articles that have reported on the anti-inflammatory activity of Coriandrum sativum L. A literature review was carried out by searching on the electronic databases including PubMed, ScienceDirect, and Google Scholar for studies pharmacological activities of Coriandrum sativum. All recent research articles published between 2010 and 2020 were included. Based on eligibility criteria, a total of 8 studies were included in this study, consisting of 3 in vitro studies, 5 in vivo studies. The set of pharmacological studies reported evidence of the Coriandrum sativum L. potential for the treatment of diseases associated with an inflammatory response. The Coriandrum sativum L. has been reported to be able to inhibit NO, iNOS, IL-1, IL-6, TNF-α, TNF-R1, ROS, COX-2, NF-kB, MAPK, and reduce edema, as well as exhibited a membrane stabilization effect by inhibiting hypotonicity-induced lysis of erythrocyte membrane. In vitro and in vivo studies strongly demonstrated that Coriandrum sativum has potential as an anti-inflammatory.