Formulation and Characterization of Oxybenzone loaded liposomes

Oxybenzone is a widely used sunscreen molecule incorporated in various sunscreen lotions and creams. The objective of the present investigation was to formulate oxybenzone as liposomes and convert them into the sunscreen creams or lotions to improve stability and enhance sunscreen efficiency and safety of the molecule. Liposomes of oxybenzone were prepared by dissolving varying amounts of lecithin and drug (2: 0.1, 3.5: 0.1 and 6: 0.1). The liposomes were evaluated for particle size, shape, zeta potential, entrapment efficiency and drug release. The liposomes were formulated as sunscreen cream and evaluated for various parameters and in vitro sunscreen efficacy. A maximum of 80.03% oxybenzone release was observed in the formulation OL3 at the end of 12th h while the lowest was observed for formulation OL5 (65.2%)