Application of 4,4′-Diaminobenzanilide Schiff Base Metal Complexes As Anti-Tumor and Anti - Dengue Agents

A unique Schiff base ligand 4-(4-nitrobenzylideneamino)-N-(4-(4-nitroobenzy lideneamino)phenyl)benzamide L has been prepared by condensing 4,4′-diaminobenzanilide and p-nitrobenzaldehyde. The cobalt(II), nickel(II) and copper(II) complexes of L were also prepared. The formation and the structure of the ligand and its complexes were confirmed by 1H-NMR, FT-IR, UV-Vis., EPR and EI- mass techniques. The synthesized complexes were docked with Human DNA topoisomerase I (PDB: 1SC7) and Dengue NS3 protease-helicase (PDB ID: 2VBC) using Auto Dock vina and Discovery studio software. The biological applications of the synthesized complexes were carried out by Cytotoxic screening analysis, DNA binding ability by using electronic spectra and Anti-Tumor activity by MTT assay. The results established that the synthesized transition metal complexes can be act as good anti-tumor and anti-dengue agents.