An Efficient and Regioselective Synthesis of Tetrazoles under Transition - Metal Free Conditions

A novel protocol for synthesisof series of tetrazoles is demonstrated via in-situformed secondary amides under transition-metal free conditions. The reaction well tolerates a wide variety of functional groups to afford structurally diverse tetrazoles in good to excellent yields at 70°C. All the synthesized compounds were characterized by FT- IR, 1H /13C NMR, LC-Mass spectral data and elemental analyses.