Biochemical and Pathological Features of Postmortem Time Interval of Natural Brain Death Induced in Albino Rats

Previously we studied certain biochemical markers of postmortem time interval (PMI) in brain stem induced death in albino rats in first 30 hours after death. PMI is very important in forensic medicine for both criminal and civil conditions. We investigate histopathology, biochemical markers of enzymology and trace minerals in brain stem death model in albino rats. In the current study, we found a time dependent reduction in cholesterol and calcium level while LDH, CPK, sodium, potassium, total protein, albumin and chloride were increased as a result of tissue degradation. Notably, triglycerides are only fluctuated chemicals in blood sera suffered postmortem changes even is the highest point near 72 hours. Histopathological changes in heart, lung and brain were also time dependent except that brain suffers sever hemorrhage at the time of death onset due to increase intracranial pressure after injection of hypotonic solution in the dura mater. On conclusions, level cholesterol and trace mineral could correlate to postmortem time interval on natural induced death.