Correlation of Serum Creatinine Based Calculation of Glomerular Filtration Rate with Measured Radio Isotope Glomerular Filtration Rate in Healthy Individuals and Chronic Kidney Disease Patients

INTRODUCTION GFR is best index of kidney function in health and disease and accurate values are needed for optimal decision making in clinical settings. Estimated GFR eGFR based on serum creatinine is first line test of kidney function. CG formula is creatinine based equation and widely applied. Tc99m DTPA Diethylene Triamine Penta Acetic acid is the most commonly used radiopharmaceutical for GFR studies. The Gate method has been most common in the routine setting. AIM AND OBJECTIVES To study correlation of serum creatinine based calculation of GFR with measured ratio isotope GFR in healthy individuals and CKD patients. To assess the accuracy of GFR as calculated by CG GFR formulae using serum creatinine against measured RI GFR Tc 99m DTPA . METHODS This study observational study, which is done in department of medicine and department of nuclear medicine at Army Hospital RandR, Delhi Cantt in CKD and healthy individuals. Our study includes a total of 100 subjects with varying renal functions which includes 50 healthy individual and 50 CKD patients. RESULTS In this study it has been observed that in healthy group CG GFR has weak correlation with DTPA GFR r = 0.104 with p 0.471 . In study it has been observed that in CKD patients CG GFR significantly correlate with DTPA. r = 0.614 with a p 0.001 . In category 79 subjects was selected with creatinine value between 0.7 to 3.7 mg dl. In this group it has been observed that CG GFR significantly correlate with DTPA. r = 0.815 with P 0.001 . In healthy subjects mean eGFR by CGGFR is 104.26 ± 31.09 range 65.4 176.2 ml min 1.73m2, whereas mean mGFR by DTPA is 92.15 ± 17.85 range 49.9 131.8 ml min 1.73m2. In healthy subjects eGFR by CGGFR overestimate the mGFR by DTPA GFR. On the other hand there is poor correlation between eGFR by formula with mGFR. In CKD subjects mean eGFR by CG GFR is 31.10 ± 14.51 range 4.74 to 57.9 ml min 1.73m2, whereas mean mGFR by DTPA is 40.06 ± 13.64 range 10.4 to 84.19 ml min 1.73 m2. In these subjects eGFR by GCGFR underestimate the mGFR by DTPA. On the other hand there is positive significant correlation p 0.001 between eGFR by both formula with mGFR. We have also observed that subjects with creatinine value between 0.7 to 3.5 mg dl, irrespective of their disease status Healthy and CKD subjects has significant positive correlation between eGFR CG GFR with mGFR DPTA p value 0.001 . It signifies that with extremes of creatinine either very low or very high value eGFR doesn't correlate with mGFR. CONCLUSION AND RECOOMANDATIONS In conclusion, the modified Gates method is undoubtedly an important method in unilateral renal function measurement. But our results implied that its performance in total GFR estimation was not better than the CG equations. Lt Col (Dr.) Rahul Soni | Dr. Jayita Debnath "Correlation of Serum Creatinine Based Calculation of Glomerular Filtration Rate with Measured Radio Isotope Glomerular Filtration Rate in Healthy Individuals and Chronic Kidney Disease Patients" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-2 , February 2021, URL: https://www.ijtsrd.com/papers/ijtsrd38443.pdf Paper Url: https://www.ijtsrd.com/medicine/other/38443/correlation-of-serum-creatinine-based-calculation-of-glomerular-filtration-rate-with-measured-radio-isotope-glomerular-filtration-rate-in-healthy-individuals-and-chronic-kidney-disease-patients/lt-col-dr-rahul-soni