Cell Cycle-Regulated Genes Classification using Machine Learning and Deep Learning Techniques on Processed Microarrays Images

Nowadays, machine learning and deep learning algorithms, are considered as new technologies increasingly used in the biomedical field. Machine learning is a branch of Artificial Intelligence that aims to automatically find patterns in existing data. A new Machine Learning subfield, the deep learning theory, has emerged. It deals with object recognition in images. In this paper, our goal is DNA Microarrays'analysis with these algorithms to classify two genes' types. The first class represents cell cycle regulated genes and the second is non cell cycle regulated ones. In the current state of the art, the researchers are processing the numerical data associated to gene evolution to achieve this classification. Here, we propose a new and different approach, based on the microarrays images' treatment. To classify images, we use three machine learning algorithms which are: Support Vector Machine, KNearest Neighbors and Random Forest Classifier. We also use the Convolutional Neural Network and the fully connected neural network algorithms. Experiments demonstrate that our approaches outperform the state of art by a margin of 14.73 per cent by using machine learning algorithms and a margin of 22.39 per cent by using deep learning models. Our models accomplish real time test accuracy of ~ 92.39 % at classifying using CNNand 94.73% using machine learning algorithms.