Long-Standing Ulcerative Colitis and Sulphasalazine Treatment Complicated by Adult Celiac Disease
Journal: International Journal of Celiac Disease (Vol.8, No. 4)Publication Date: 2020-12-30
Authors : Hugh James Freeman;
Page : 117-119
Keywords : celiac disease; Sulphasalazine; ulcerative colitis; serological screening;
Abstract
The risk of celiac disease may be increased in patients with inflammatory bowel disease (IBD), however, the precise pathogenetic mechanisms involved remain controversial. In this report, an elderly man with long-standing and extensive ulcerative colitis was treated with daily salazopyrine for over 30 years. His medication was eventually discontinued although endoscopic surveillance studies showed healed colitis with minimal inflammatory change and no dysplasia. He subsequently volunteered as an IBD control in a celiac disease research study. Endomysial and tissue transglutaminase antibodies were unexpectedly positive and a small bowel biopsy showed changes of celiac disease that later responded to a gluten-free diet. Earlier historical duodenal and ileal biopsies had been normal suggesting that changes were new, developing after cessation of the salazopyrine. This unusual presentation “unmasking” celiac disease after cessation of long-standing salazopyrine for colitis raises the potential that the drug may have acted to suppress the inflammatory process in celiac disease and may offer another alternate and inexpensive therapeutic approach.
Other Latest Articles
- The Relationship between Sports Industry Development and Economic Growth in China
- Analysis of the Influence of Economic Potential on Inequality of Economic Zones between Regencies / Cities in South Sumatra Province
- Analysis of the Effect of Domestic Investment, Exports and Labor in the Agricultural Sector on the Economic Growth in South Sumatra Province
- Does the Use of E-learning Media for Economic Disciplines Effective during the COVID 19 Pandemic?
- Expert Verification of Accounting Information on Financial Instruments for Solving Economic Crimes
Last modified: 2021-05-04 02:10:13