Transfersomes: A Peculiar and Promising Technique for Transdermal Drug Delivery

Novel drug delivery systems are now a days is creating a new interest in development of drug deliveries. Vesicular drug delivery system is also a part of these novel drug delivery systems. Transport of the drug through skin is best route of drug delivery because the skin is largest organ in human body. Drug carries which are used in transdermal drug delivery such as liposomes, niosomes, or micro emulsions pose a problem that they remains mostly confined to the skin surface and therefore do not transport drugs efficiently through the skin. Because of the deformable nature of transferosomes, it penetrates through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form. The preparation variables are depending upon the procedure involved for manufacturing of formulation and the preparation procedure was accordingly optimized and validated. Vesicle shape and size, entrapment efficiency, degree of deformability, number of vesicles per cubic mm can be characterised by in-vitro studies. Thus, they act as a carrier for low as well as high molecular weight drugs e.g., analgesic, anaesthetic, corticosteroids, sex hormone, anticancer, insulin. Transferosomes thus differs from such more conventional vesicles primarily by its softer, more deformable, better adjustable artificial membrane.