Cytotoxic Activity of Piper cubeba: A Review

Several studies show P. cubeba has cytotoxic activity and has the potential to be used in cancer therapy. This article aims to review the cytotoxic activity of P. cubeba. We collected research articles from several databases, including PubMed, Sciencedirect, and Google Scholar. The keywords used are "Anticancer" OR "Cytotoxic" AND "P. cubeba". The cytotoxic activity of P. cubeba has been tested on several cancer cells lines including MCF-7, HT29, MDA-MB-468, MDA-MB-231, A549, K562, SiHa, KB, HCT116, HT29, and HTC, mainly using MTT methods. The cytotoxic activity of P. cubeba belonged to the strong and toxic categories. This activity is influenced by the part of the plant used, the type of solvent and the dose tested and also the presence of amide and lactone groups from (–)-cubebin