ROLE OF THE TTN, TTN-TRUNCATION, MMP-2 AND MMP-3 GENES POLYMORPHISMS IN THE DEVELOPMENT OF ANTHRACYCLINEINDUCED CARDIOMYOPATHY

The given review is devoted to the problem of cardiotoxicity of chemotherapeutic agents. The antitumor antibiotics anthracyclines can cause cardiomyopathy, which may predict worse prognosis in cancer patients and be an independent cause of death. Identification of patients at high risk of cardiotoxicity is the first step towards successful prevention of heart failure in cancer patients. Genetic typing is an effective measure to predict an increased risk of cardiotoxic effects of anthracyclines. The review article analyzes the role of gene mutations in the development of chemotherapy-induced heart failure.